Endocrine Abstracts

Introduction: VPA, antiepileptic drug, may cause a number of side effects including reproductive deficits in humans. Previously we found that VPA (1 μM) may suppress GnRH-stimulated release of LH from rat anterior pituitary cells in vitro without affecting its basal secretion (Neuroendocrinol Lett 2011 32 101–106). However mechanism of VPA suppressive activity is still unknown. Since pharmacological effects of VPA require GnRH-R activation, the m...